Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate
decoquinate
CAS: 18507-89-6
Molecular Formula: C24H35NO5
Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate - Names and Identifiers
| Name | decoquinate |
| Synonyms | Decox e 756 deccox Deccox decoquinate DECOQUINATE DECCOX(DECOQUINATEPREMIX) Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate Ethyl6-(decyloxy)-7-ethoxy-4-hydroxyquinoline-3-carboxylate ethyl 6-(decyloxy)-7-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate 3-Quinolinecarboxylic acid, 6-(decyloxy)-7-ethoxy-4-hydroxy-, ethyl ester |
| CAS | 18507-89-6 |
| EINECS | 242-389-1 |
| InChI | InChI=1/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26) |
Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate - Physico-chemical Properties
| Molecular Formula | C24H35NO5 | ||
| Molar Mass | 417.54 | ||
| Density | 1.091±0.06 g/cm3(Predicted) | ||
| Melting Point | 241.0 to 245.0 °C | ||
| Boling Point | 517.9±45.0 °C(Predicted) | ||
| Flash Point | 279°C | ||
| Solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) | ||
| Vapor Presure | 1.25E-11mmHg at 25°C | ||
| Appearance | Pale yellow crystal | ||
| Color | Off-White to Pale Beige | ||
| Merck | 14,2854 | ||
| pKa | 2.60±0.50(Predicted) | ||
| Storage Condition | Inert atmosphere,Room Temperature | ||
| Refractive Index | 1.514 | ||
| Physical and Chemical Properties | This product is white or yellowish crystalline powder, odorless; This product is very slightly soluble in chloroform or ether, insoluble in water or ethanol. | ||
| Use | Antigenic insect drug for chicken coccidiosis. |
Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | VB1983800 |
| HS Code | 29334900 |
Ethyl 6-decyloxy-7-ethoxy-4-hydroxy-3-quinolinate - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| High-efficiency anticoccidial drugs for livestock and poultry | Decoquine ester is a new type of quinolone high-efficiency anticoccidial drugs for livestock and poultry, commonly known as decoquine ester, Edecoquine ester, Endocin, Dicoquine ester, Benzoquine methyl ester, the original drug is white or slightly yellow crystalline powder, it is very slightly dissolved in chloroform or ether, insoluble in water or ethanol, and has a unique anti-coccidial activity. The anti-coccidial activity effect is stronger than that of Madumiin ammonium, nicarbazine ethoxyamidobenzene methyl ester, methyl salinomycin, studies have shown that decoquine ester can effectively defeat the resistance of coccidia, clinically, it is used to prevent and control the most harmful to poultry. Poultry coccidiosis caused by six species of coccidia, such as Eimeria (E.tenella), giant Eimeria (E.maxima), pile-type Eimeria (E.acerVulina), poisonous Eimeria (E.necatrix), Eimeria brucei (E.brunetti), and transposed Eimeria (E.mivati). It can also prevent and control neosporidiosis in cattle, sheep and other domestic animals and cryptosporidiosis in ruminants; it can also increase the weight gain rate and milk yield of young goats. Decoxyquinate plays a role in the asexual reproduction stage of coccidia. After entering the sporozoite cells, it interferes with DNA synthesis and prevents its development. It starts to play a role in the early life history of coccidia, effectively avoiding intestinal damage caused by coccidia. The addition of the feed will not affect the digestion of the feed and the absorption of nutrients by the power. This product has no incompatibility; it cannot be used in feed containing bentonite. Quinoline anticoccidial drugs are easy to produce drug resistance. It is recommended to use it only during the peak period of coccidia outbreak, and the maximum continuous use should not exceed 4 weeks. Since the 2070s, decoquine has been widely used in the prevention and control of avian coccidiosis in many countries, but it has not been used in China. In 2006, the American Yalai company was first introduced and sold in the Chinese market, which attracted great attention and widespread attention. The reasons are as follows: it was first used in China, without drug resistance, and it was the most ideal rotation drug to kill coccidia and promote growth. Growth, improve coloring, have excellent anti-coccidia effect and growth-promoting performance; it began to play a role in the early life history of coccidia, and lasted for the longest time; it has a wide spectrum of resistance to coccidia and has good effects on the 6 most harmful species of avian coccidia; it has good stability and can maintain stable quality within 4 years under suitable temperature and humidity conditions. at present, there are many manufacturers in China, such as Hangzhou hairxi animal husbandry technology co., ltd., Shandong xinde technology co., ltd. and so on, which are producing and selling decoquine raw materials. |
| toxicity | low toxicity and good tolerance; It is still safe to use 80 times the recommended amount. Metabolism is fast. After 3 days of drug withdrawal, the residual drug concentration in each tissue is lower than 1 × 10-6. poultry: 800ppm(26 times the normal amount) was added to the feed, and the feed was continuously fed for 127 days without poisoning. Pigs: continuous feeding at 800ppm for 10 days without poisoning. |
| pharmacokinetics | absorption is fast, and the effective concentration of anti-coccidia can be reached within 1 hour, and the concentration reaches the peak level after 3 days. After 5 days and 7 days of administration of the last-labeled decaquinyl ester in cattle and sheep, respectively, a single dose of 14C-labeled product was given to cattle and sheep for intravenous injection. After 1.5 hours, the plasma radiation reached its peak. There is partial metabolism in rats, producing 3 kinds of metabolites, and its structure cannot be determined. In ruminants, only two metabolites are determined, and the proportion is lower than that of rats. The main excretion route of ruminants is feces, followed by urine. In sheep, the total dose of 36% is excreted in the urine, 35% is excreted within 24 hours, and decoquine and metabolites are completely excreted in the urine within 3 days. |
| combination medication | in order to improve the effect of anti-coccidia and reduce the occurrence of drug resistance, combination medication can be adopted. In the early stage of coccidiosis (the asexual reproduction period of coccidia), the combination of decoxyquinoate dicepuril or totrazuril, diamidin ammonium, and dichloropyridine can play a synergistic role of drugs. Enhance the killing effect, and at the same time reduce the dose of each drug by 1/2. In the whole period of coccidiosis, combined medication regimens such as dichostatin sulfaquinoxaline sodium and dichostatin sulfaclopyrazine sodium can be used, so that coccidia in the asexual reproduction period and the sexual reproduction period can be inhibited and killed at the same time. |
| use | quinoline coccidioides. As a feed additive to prevent coccidiosis in broilers, 1t feed is added with 27.2g of this product. The product has low toxicity, good tolerance and wide safety range. Metabolism is rapid, and the concentration of residual drug in each tissue is less than 1ppm after 3 days of drug withdrawal. Antigenic insect medicine, used for chicken coccidiosis. |
| Production method | 3, 4-dihydroxynitrobenzene reacts with bromodecane in DMF medium to generate 3-hydroxy-4-decyloxy nitrobenzene. Then it is ethoxylated and reduced to prepare 3-ethoxy-4-decyloxyaniline. Then, 3-ethoxy-4-decyloxyaniline is condensed with diethyl ethoxymethylene malonic acid to obtain 3-ethoxy-4-decyloxyanilinyl methylene malonic acid Diethyl ester, and finally the finished product is obtained by heat condensation via thermal condensation. |
Last Update：2024-04-10 22:43:14
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